Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy
نویسندگان
چکیده
منابع مشابه
Effect of Silver Nanoparticles on Improving the Efficacy of 5-Aminolevulinic Acid-Induced Photodynamic Therapy
Introduction: The most important limitation of 5-aminolevulinic acid (5-ALA)-induced photodynamic therapy (PDT) is the efficacy of the cells in converting 5-ALA to protoporphyrin IX. The present study aimed to investigate the effectiveness of silver nanoparticles (AgNPs) with the photosensitivity at the surface plasmon resonance wavelength on 5-ALA-mediated PDT. Material and Methods: First of a...
متن کاملThe inhibition of ferrochelatase enhances 5-aminolevulinic acid-based photodynamic action for prostate cancer.
BACKGROUND The aim of this study was to clarify the mechanism of accumulation of 5-aminolevulinic acid (ALA)-dependent protoporphyrin IX (PpIX), ALA-photodynamic therapy (PDT)-induced cell death and enhanced efficiency by a ferrochelatase inhibitor in prostate cancer PC-3 cells. METHODS The accumulation of ALA-induced PpIX in PC-3 cells was observed by fluorescence microscopy and measured by ...
متن کاملDerivatives of 5-Aminolevulinic Acid for Photodynamic Therapy
Photodynamic therapy (PDT) is a clinical treatment that combines the effects of visible light irradiation with subsequent biochemical events that arise from the presence of a photosensitising drug (possessing no dark toxicity) to cause destruction of selected cells. Today, the most common agent used in dermatological PDT is 5-aminolevulinic acid (ALA). As a result of its hydrophilic character, ...
متن کاملPhotodynamic therapy of human glioma spheroids using 5-aminolevulinic acid.
The response of human glioma spheroids to 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) is investigated. A two-photon fluorescence microscopy technique is used to show that human glioma cells readily convert ALA to protoporphyrin IX throughout the entire spheroid volume. The central finding of this study is that the response of human glioma spheroids to ALA-mediated PDT depend...
متن کاملTherapeutic effects of topical 5-aminolevulinic acid photodynamic therapy
OBJECTIVE To evaluate the therapeutic effects of combined 5-aminolevulinic acid (ALA) and photodynamic therapy (PDT) on genital warts and the safety. METHODS One hundred ten patients with genital warts who were treated in our hospital from June 2013 to October 2014 were selected. The warts and affected parts were disinfected with benzalkonium bromide solution, and the warts were covered with ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2019
ISSN: 0007-0920,1532-1827
DOI: 10.1038/s41416-019-0586-3